Microscale Robotics Lab
We bridge biology and engineering by translating cellular mechanisms into vesicle-based microrobots. Using synthetic biology and soft-matter physics, we develop biomimetic platforms for precision micro-medicine and cellular modeling.
Our Vision
Our research is driven by a fundamental question: how can we replicate the autonomous behaviors of living cells within synthetic architectures? We investigate the properties of lipid membranes and the principles of active matter to engineer GUV-based microrobots capable of micro-scale navigation. By treating vesicles as programmable, biomimetic building blocks, we move beyond passive carriers toward intelligent systems designed to interact with and navigate complex biological environments.
Research Pillars
Autonomous Synthetic Motility
Encoding the principles of cellular interstitial migration into GUV-based, active particle-driven architectures. We create intelligent microrobots capable of autonomous navigation through the structured complexity of biological environments.
Tumour Tissue Penetration
Harnessing the extreme deformability of ultra-soft vesicle platforms to cross biological barriers. We engineer these systems to penetrate dense pathological environments under the precision of controlled external fields.
Endogenous Actuation & Bioresorbability
Developing active systems powered by internal biological substrates. By using biocompatible and bioresorbable materials, we ensure safe, temporary residency within the body alongside targeted therapeutic action.
Biomimetic Models for Validation
Designing high-fidelity in vitro assays and microfluidic environments for the ethical validation of micro-scale devices, to provide robust, scalable alternatives to animal models in line with 3R principles.
Lab Expertise & Capabilities
GUV Engineering & Characterization
Controlled micro-encapsulation of particles and molecules within lipid vesicles. Our workflow includes membrane functionalization and biophysical assessment, supported by the systematic refinement of protocols to improve vesicle size distribution, population yield, and encapsulation efficiency.
Active Matter Synthesis & Dynamics
Fabrication of Janus particles via monolayer formation and physical vapor deposition, with structural validation through SEM and AFM. We perform quantitative analysis of out-of-equilibrium dynamics using automated particle tracking and numerical simulations to evaluate system behavior.
Advanced Optical Microscopy
Quantitative visualization and data acquisition using Phase Contrast, Fluorescence, and Confocal microscopy. We monitor and analyse membrane dynamics, encapsulation stability, active particle motility, and the navigation of microrobots within 3D environments.
In Vitro Model Fabrication
Development of custom "organ-on-a-chip" environments to simulate physiological and pathological flows. We leverage high-resolution 3D (bio)printing to create biomimetic and cell-laden scaffolds for the 3R-compliant evaluation of micro-scale devices.
Remote Actuation & Control
Expertise in the magnetic and acoustic actuation of synthetic cells and microrobots. We utilize these modalities to study and refine navigation strategies within complex biological mimics and structured media.
Open Science & Reproducibility
We prioritize rigour, reproducibility, and transparency in our research activities and the open sharing of our research methods and outputs. Our methodologies and results are frequently published in Open Research Europe, with supporting data and custom code made accessible through our Zenodo Community and GitHub Organization.
Collaborate with us
We are always open to new partnerships at the intersection of synthetic biology, soft active matter, and micro-medicine. Whether you are seeking scientific synergy or exploring translational R&D, we invite you to discuss how our expertise and infrastructure can support your project.
