HAND2 is a research project funded by the Young Researcher program of the Italian Ministry of University and Research (MUR). This 3-year project will be carried on within the Artificial Hands Area of ​​the BioRobotics Institute and is intended as a consequential and complementary extension of the HAND project, precedently funded by the Marie Skłodowska-Curie Actions program of the European Union. HAND2 therefore continues the mission of developing and validating methods for prosthetic hands which are semi-autonomous from the conventional myoelectric human-machine interface. This goal will be pursued by finalizing the exploratory work carried out in the previous project on modern sensors and artificial intelligence, and modelling of the “reaching” movement. Specifically, the ambitious goal is to develop a complete prosthetic system able to intuitively manage the main phases of human-object interaction, from grasp planning, to reaching, up to the actual grasping for manipulation. Such a system will be able to 1) recognize the target object from a distance to enable the desired grasp on a multi-articulated prosthetic hand, 2) optimize and execute digits trajectories for grasping during the reaching phase, and 3) recognize the properties of the target object to ensure an adequate grasp once it is in contact with the prosthesis. Semi-autonomous prosthetic hands can be a game changer, ultimately transforming the conventional view of a prosthetic hand from a tool to a more complex device that interacts in an intelligent fashion with the user and any object.